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CBD and Autism

CBD and Autism

A recently published observational study on the effects of CBD-Enriched cannabis extract on Autism Spectrum Disorders highlights the need for double-blind placebo-controlled studies to evaluate the effectiveness of CBD on Autism.Many autism symptoms are related to neuronal hyperexcitability, and CBD may reduce multiple autistic symptoms, with relatively lower side effects.The standardized extract ...

β-Caryophyllene (BCP) and Neurodegenerative Disorders

β-Caryophyllene (BCP) and Neurodegenerative Disorders

Neurodegenerative disorders such as dementia, multiple sclerosis (MS), and Alzheimer's disease (AD) share neuroinflammatory characterization.CB2 receptor agonists have shown neuromodulatory and immunomodulatory effects in the immune system.β-Caryophyllene (BCP) is a CB2 agonist found in natural products such as cannabis, black pepper, Thai basil, and cloves. It has displayed anti-inflammatory and...

Atypical cannabinoid targets

Atypical cannabinoid targets

Cannabinoids effects on the central and peripheral nervous systems are primarily attributed to two G-protein-coupled receptors; cannabinoid receptors type 1 and type 2 (CB1 and CB2, respectively). Phytocannabinoids show different affinities for CB1 and CB2 receptors. Cannabidiol or CBD has a low affinity for the CB1 and CB2 receptors and acts as an antagonist of CB1 and CB2 agonists.In many cases,...

Cost-effectiveness of medical cannabis in treating chronic pain

Cost-effectiveness of medical cannabis in treating chronic pain

The opiate crisis is a pressing public health issue in Canada and the US. The death associated with the use of opioids may impact the life expectancy of Canadians (Source). It seems that currently approved medications for treating opioid use disorder (OUD) are not risk-free or effective in all patients and we need alternatives to manage patients with chronic pain or OUD (Source). Medical Cannabis...

Antineoplastic properties of cannabinoids

The potential role of phytocannabinoids and the endocannabinoid system (ECS) in confining malignant tumours is among the most discussed topics in the field of medical cannabis. There are countless anecdotes from patients and even clinical studies (usually small ones) about the effect of cannabinoids on controlling different cancer types. Many patients also believe that cannabis and its derivative...

Can cannabinoids and particularly CBD be an adjunct therapy for Colorectal Adenocarcinoma?

Adenocarcinoma is the most common type of colorectal cancer. The inhibition of the cancer cell proliferation and induction of apoptosis in cancer cells by CB1 and CB2 activation has been reported. A recent study by Cerretani et al., demonstrated that CBD-induced cytotoxicity in HT-29 cells occurs through a CB1 and CB2 receptor-independent mechanism. [caption id="attachment_1612" align="aligncent...

New consensus-based recommendations for titrating cannabinoids and tapering opioids for chronic pain management

New consensus-based recommendations for titrating cannabinoids and tapering opioids for chronic pain management

An analysis by the United Nations Office on Drugs and Crime (UNODC) in 2016 reported that Canada had the highest consumption of opioids per capita in the world. In order to understand the pattern and trend of prescribing opioids in Canada, CIHI's (Canadian Institute for Health Information) scientists analyzed data from the National Prescription Drug Utilization Information System (NPDUIS) and Ont...

Cannabis strains used in research in the US are more similar to hemp

Can we generalize the result of clinical studies to patients' experience? The genetics of cannabis strains used in research in the US is different from commercially available products. Therefore, the clinical effect of the studied strains may be different from the patient-reported outcomes. A recent study analyzed the genetics of 49 cannabis strains from various sources including NIDA (National ...

Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review

The result of this systematic review indicated that while HCPs (Healthcare Professionals) believed that medical cannabis is a viable useful therapeutic option for patients, they do not have enough knowledge and formal education to make the best decision for their patients. Consequently, they reject to prescribe or support patients to use medical cannabis or they get the information from unreliable...